Table 1. Demographics and Clinical Characteristics of Initial Malaria Episode.
| Treatment Group | ||||||
| CQ Monotherapy (N = 160) | CQ+Artesunate (N = 160) | CQ+Azithromycin (N = 160) | CQ+Atovaquone-proguanil (N = 160) | All Subjects (N = 640) | ||
| Gender | ||||||
| All Subjects | Female | 77 (48.1%) | 70 (43.8%) | 73 (45.6%) | 82 (51.3%) | 302 (47.2%) |
| N(%) | Male | 83 (51.9%) | 90 (56.3%) | 87 (54.4%) | 78 (48.8%) | 338 (52.8%) |
| Age | ||||||
| All Subjects | >6 to 12 months | 16 (10.0%) | 14 (8.8%) | 12 (7.5%) | 14 (8.8%) | 56 (8.8%) |
| N(%) | >1 to 3 years | 79 (49.4%) | 81 (50.6%) | 79 (49.4%) | 78 (48.8%) | 317 (49.5%) |
| >3 to 5 years | 65 (40.6%) | 65 (40.6%) | 69 (43.1%) | 68 (42.5%) | 267 (41.7%) | |
| Weight (kg) * | ||||||
| ≥6 to 12 months | Mean (SD) | 8.0 (0.67) | 8.4 (1.23) | 8.3 (0.94) | 8.4 (1.80) | 8.2 (1.21) |
| ≥1 to 3 years | Mean (SD) | 11.1 (1.75) | 11.0 (1.65) | 11.3 (1.47) | 10.9 (1.47) | 11.1 (1.59) |
| ≥3 to 5 years | Mean (SD) | 13.4 (1.60) | 13.5 (1.57) | 13.3 (1.62) | 13.6 (1.50) | 13.4 (1.57) |
| Stature (cm) * | ||||||
| ≥6 to 12 months | Mean (SD) | 69.7 (3.45) | 69.5 (4.03) | 69.5 (2.85) | 70.8 (8.53) | 69.9 (5.12) |
| ≥1 to 3 years | Mean (SD) | 83.0 (5.95) | 82.0 (5.94) | 83.6 (5.31) | 81.7 (5.16) | 82.6 (5.63) |
| ≥3 to 5 years | Mean (SD) | 95.1 (7.21) | 94.2 (5.19) | 94.3 (6.24) | 95.3 (5.29) | 94.7 (6.02) |
| Parasite Density/mm3 | ||||||
| All subjects | Geometric Mean | 21,413 | 21,470 | 23,399 | 19,341 | 21,358 |
| (min, max) | (1,880, 191,800) | (2,006, 191,800) | (2,401, 191,500) | (2,040, 189,198) | (1,880, 91,800) | |
| Hemoglobin (g/dL) | ||||||
| ≥6 to 12 months | Mean (SD) | 9.0 (1.27) | 8.7 (1.95) | 9.2 (1.29) | 8.9 (1.48) | 9.0 (1.49) |
| (min, max) | (6.2,10.5) | (5.5, 10.9) | (7.2, 11.1) | (7.0, 11.4) | (5.5, 11.4) | |
| ≥1 to 3 years | Mean (SD) | 9.8 (1.60) | 9.6 (1.88) | 10.0 (1.78) | 9.7 (1.87) | 9.7 (1.78) |
| (min, max) | (5.5, 14.3) | (5.5, 16.0) | (5.6, 14.3) | (5.6, 15.0) | (5.5, 16.0) | |
| ≥3 to 5 years | Mean (SD) | 9.5 (1.70) | 10.5 (1.75) | 10.1 (2.03) | 10.0 (1.71) | 10.0 (1.83) |
| (min, max) | (5.7, 13.9) | (5.7, 14.2) | (5.8, 16.5) | (6.3, 13.0) | (5.7, 16.5) | |
| Enrollment Season †† | ||||||
| All subjects | Peak Malaria Season | 52 (32.5%) | 52 (32.5%) | 54 (33.8%) | 51 (31.9%) | 209 (32.7%) |
| Off-peak Malaria Season | 108 (67.5%) | 108 (67.5%) | 106 (66.3%) | 109 (68.1%) | 431 (67.3%) | |
*
7 subjects missing baseline weight and stature measurements.
††
Peak malaria season is defined as 01 Dec through 31 March.