Table 2. Top 5 most significantly dysregulated pathways identified by SILAC and subsequent IPA-Tox analysis.

Pathways identified by IPA-Tox Analysis	Number of dysregulated proteins out of total number of proteins detected per pathway	p-value
Mitochondrial dysfunction	22/137	<0.001
Oxidative stress	13/57	<0.001
Cholesterol biosynthesis	6/16	<0.001
Increases transmembrane potential of mitochondria and mitochondrial membrane	9/50	<0.001
Hypoxia-inducible factor signaling	10/70	0.002

WM1158 cells treated for 4 hr with Elesclomol (500 nM) or only DMSO.