Table 1. Clinical and biological characteristics of liver metastatic (n = 27) versus non-metastatic (n = 31) sporadic colorectal carcinoma (sCRC) patients.
| Liver metastatic sCRC (n = 27) | Non-metastatic sCRC (n = 31) | p-value | Total cases (n = 58) | |
| Age (years)* | 73 (48–80) | 72 (38–83) | NS | 72 (38–83) |
| Gender | ||||
| F | 11 (41%) | 9 (29%) | NS | 20 (34%) |
| M | 16 (59%) | 22 (71%) | 38 (66%) | |
| Tumor Localization | ||||
| Rectum | 5 (19%) | 11 (36%) | 16 (28%) | |
| Left colon | 13 (48%) | 15 (48%) | NS | 28 (52%) |
| Right colon | 9 (33%) | 5 (16%) | 14 (20%) | |
| Histological grade | ||||
| Well-differentiated | 16 (59%) | 23 (74%) | 39 (67%) | |
| Moderate-differentiated | 8 (30%) | 7 (22%) | NS | 15 (26%) |
| Poorly-differentiated | 3 (11%) | 1(4%) | 4 (7%) | |
| Histopathology | ||||
| pN0 | 7 (26%) | 31 (100%) | 38 (66%) | |
| pN1 | 12 (44%) | 0 (0%) | p≤0.001 | 12(21%) |
| pN2 | 8 (30%) | 0 (0%) | 8 (13%) | |
| Tumor Size (cm)# | 5 (2.5–9) | 5 (2.5–14) | NS | 5 (2.5–14) |
| Serum ALP (mg/dl) | 94 (1–330) | 108 (55–495) | NS | 101 (1–495) |
| Serum CEA (ng/ml) | 45.4 (0.8–4598) | 3.2 (0.6–84) | p≤0.001 | 7.2 (0.6–4598) |
| Deaths | 20 (74%) | 3 (10%) | p≤0.001 | 23 (40%) |
| Median OS (months)* | 25 | Not Reached | p≤0.001 | Not Reached |
*
Results expressed as median (range) or
#
as number of cases (percentage); NS: statistically not significant (p>.05); F: female; M: male; ALP: alkaline phosphatase; CEA: Carcinoembryonic antigen; OS: overall survival.