Table 1.
Clinico-hematological profile of five patients with plasma cell leukemia
| Patient no | 1 | 2 | 3 | 4 | 5 |
|---|---|---|---|---|---|
| Age (years) | 46 | 62 | 37 | 45 | 45 |
| Sex | M | M | M | F | F |
| Chief complaints | Easy fatigability | Abdominal distension, pedal edema, decreased appetite | Fever, abdominal pain | Chest pain | DUB, multiple subcutaneous nodules |
| Duration | NA | 15 days | 1 month | 1 week | 2 months |
| Hepatomegaly | + | + | + | − | + |
| Splenomegaly | − | + | + | − | + |
| Lymphadenopathy | − | − | − | + | + |
| Any other finding | − | Ascitis | − | CXR-mediastinal widening USG abdomen-multiple intra-abdominal lymph nodes | − |
| Bony lytic lesions | + | − | − | − | − |
| Hb (g/l) | 60 | 60 | 36 | 90 | 57 |
| TLC × 109/l | 18.8 | 34.3 | 59.5 | 24.8 | 75.0 |
| Platelet count × 109/l | 100 | 92 | 11 | 207 | 32 |
| % of Plasma cells in peripheral smear | 60 | 70 | 39 | 51 | 79 |
| Morphology | Lymphoplasmacytic | Plasmacytic | Lymphoplasmacytic, plasmacytic, plasmablastic | Plasmacytic, | Plasmacytic, lymphoplasmacytic |
| Bone marrow (BM) | Hypercellular, 65% plasma cells and plasmablasts | Hypercellular, 70% plasma cells | Hypercellular, 44% plasma cells, lymphoplasmacytoid cells and plasma blasts | Hypercellular, 90% plasma cells many with anaplastic morphology | Post mortem BM biopsy- diffuse infiltration by plasma cells |
| IHC on biopsy (Bx) | NA | NA | BM Bx | BM Bx | Skin Bx |
| Kappa +, Lambda − | Lambda +, Kappa − | Kappa +, Lambda − | |||
| Urine BJP | − | NA | − | − | NA |
| SPE (M Band) | + | NA | − | NA | NA |
NA not available, + present, − absent