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. Author manuscript; available in PMC: 2013 Oct 1.
Published in final edited form as: Leuk Res. 2012 Jul 17;36(10):1267–1273. doi: 10.1016/j.leukres.2012.06.014

Figure 3. G-banding karyotype, FISH and SKY for BJAB cells.

Figure 3

G-banding showed 3 chromosomes 7 and 2 chromosomes 12 in BJAB cells. However, dualcolor interphase FISH showed that 90% of the cells have 2 green signals for SMO and 2 red signals for centromere 7 (ratio 1:1) indicating the presence of 2 chromosome 7 and 2 copies of SMO. Few cells showed 2 SMO signals and 3 centromeric signals indicating that a subset of cells has trisomy 7 and a deletion involving the long arm on chromosome 7 (not shown). SKY analysis confirmed the presence of trisomy 7 with one derivative 7 having its long arm replaced with DNA from another chromosome.