Table 3.
Serum neutralizing antibody (SNA) seroresponse rates and vaccine efficacy (Prot) against severe RVGE in selected RV5 studies.
| Strain Serotype | Bangladesh and Vietnam OPV [27] | Ghana, Kenya and Mali OPV [28] | Latin America OPV [30] | US and Finland No OPV [5] | ||||
|---|---|---|---|---|---|---|---|---|
| % SNA | % Prot | % SNA | % Prot | % SNA | % Prot | % SNA | % Prot | |
| G1 | 32.1 | 46.2 | 18.5 | 32.3 | 59.9 | NR | 76 | 74.9* |
| G2 | 9.9 | 29.2 | 9 | 27.1 | 36.3 | NR | 34.3 | 63.4* |
| G3 | 28.2 | 67 | 6.3 | 62.3 | 29.3 | NR | 22.1 | 82.7* |
| G4 | 18.3 | NR | 26.5 | NR | 50.9 | NR | 54.1 | 48.1* |
| P1A [8] | 27.5 | 49.7 | 14.4 | 36.1 | 43.9 | NR | 53.7 | NR |
Clinical efficacy calculated for RVGE of any severity.
NR = not reported.