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A. MYPT1•PP1•CPI-17, B. GADD34•PP1•I-1. In the new PP1 heterotrimer model, PP1 inhibitor protein (cyan) directly binds to a complex of PP1 catalytic subunit (red) and regulatory subunit (purple). The direct contact between PP1 inhibitor protein and regulatory subunit may contribute to the specific recognition of PP1 holoenzymes.
