Table 6.
List of hormonal, non-hormonal and neurosteroid-based agents tested in catamenial epilepsy.
| Drug | Mechanism | Efficacy | Limitations |
|---|---|---|---|
| Hormonal agents: | |||
| Medroxyprogesterone acetate | P analogue | Mixed | Reproductive dysfunction |
| Clomiphene | Estrogen receptor antagonist | Moderate | Reproductive dysfunction |
| Triptorelin | GnRH analogue | Moderate | Menopausal symptoms |
| Leuprolide | GnRH analogue | Moderate | Menopausal symptoms |
| Progesterone | Neurosteroid precursor | High | Hormonal side effects |
| Non-hormonal agents: | |||
| Acetazolamide | Carbonic anhydrase inhibitor | Moderate | Tolerance |
| Clobazam | GABA-A receptor modulator | Moderate | Sedation/tolerance |
| Lamotrigine | Sodium channel blocker | Moderate | Dizziness, pilot study |
| Neurosteroid-based agents: | |||
| Ganaxolone | GABA-A receptor modulator | High | Small pilot study |