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. Author manuscript; available in PMC: 2013 Aug 21.
Published in final edited form as: J Am Coll Cardiol. 2012 Jul 18;60(8):775–785. doi: 10.1016/j.jacc.2012.04.027

Figure 2. S100A12 expression in thoracic aortic aneurysm dissection (TAAD).

Figure 2

(A) Co-staining for S100A12 (brown color) and myeloperoxidase (MPO, blue color) shows S100A12 expression in MPO-negative smooth muscle cells (A1) and in inflammatory MPO-positive cells (A2). (B, B1) Expression of S100A12 is most intense near the dissection tear, and colocalizes to caspase 3 (C and C1) positive cells near the dissection tear. scale bar = 10μm. (D) Verification of S100A12 protein by immunoblot. Quantification of S100A12 (E) and caspase 3 (F) expression in patients with unstable TAAD (n=14) and stable TAA >5.5 cm (n=16).