Table 1.
Comparison of currently available low molecular weight heparins (LMWH). Dosage recommendations refer to a standard 4-h dialysis session. Adult single bolus dosages for patients 50–100 kg in IU unless otherwise specified. Pediatric dosages for a 50-kg or heavier child/adolescent, unless otherwise specified [13–19]. Average molecular weight (MWt) kDa, ratio of inhibitory activity to factor IIa (thrombin) to activated factor X (Xa). Average half-life given; note that half-lives vary with residual renal function
| LMWH | MWt kDa | Half-life (h) | IIa/Xa | Adult dose | Pediatric dose |
|---|---|---|---|---|---|
| Tinzaparin | 5.0 | 4.5 | 1.9 | 1,500–3,500 | 50 IU/kg |
| Dalteparin | 6.0 | 5.0 | 2.7 | 5,000 | 40 IU/kg |
| < 15 kg 1,500 | |||||
| 15-30 kg 2,500 | |||||
| 30–50 kg 5,000 | |||||
| Reviparin | 4.0 | 5.0 | 3.5 | 85 IU/kg | 85 IU/kg |
| Nadroparin | 4.5 | 5.0 | 3.6 | 3,800–5,700 | 114 IU/kg |
| 70 IU/kg | < 50 kg 3,000 | ||||
| Enoxaparin | 4.2 | 27.7 | 3.8 | 0.5–0.7 mg/kg | 24–36 mg/m2 |
| 0.5–1.0 mg/kg |