Table 2. Brain Regions that Changed between Responders and Nonresponders as a Function of SSRI and Placebo Treatments.

Brain region	MNI coordinatea			z Value	P-value
	x	y	z
SSRI resp <SSRI nonresp (n=20/15)
R amygdala	26	−4	−26	2.08	0.019b
L amygdala	−16	−6	−14	1.65	0.049b
R orbitofrontal cortex (11)	24	42	−14	4.04	0.005
L anterior cingulate cortex (32)	−14	40	16	3.33	0.047
SSRI nonresp <SSRI resp (n=15/20)
L amygdala	−26	−8	−14	2.52	0.006b
L insula	−46	−14	2	3.61	0.028
Placebo resp <placebo nonresp (n=11/26)
L amygdala	−16	−6	−14	3.15	0.012
R amygdala	28	−2	−26	2.42	0.008b
Placebo nonresp <placebo resp (n=26/11)
R brainstem, pons	12	−16	−30	3.43	0.049
SSRI resp <placebo resp (n=20/11)
NS
Placebo resp <SSRI resp (n=11/20)
NS

Abbreviations: L, left side; R, right side; SSRI, selective serotonin reuptake inhibitor; nonresp, nonresponders; NS, not significant; resp, responders.

Approximate Brodmann's areas within parentheses.

^aBased on the Montreal Neurologic Institute coordinate system.

^bP-value uncorrected for multiple comparisons. All analyses are regions of interest (ROI)-based.