Figure 2.

Systemic administration of the acetylcholinesterase inhibitor galantamine dose-dependently attenuated nicotine, but not food, self-administration. (a) Total number of responses (mean±SEM) on the active and inactive levers following systemic administration of 0, 0.1, 1.0, or 5.0 mg/kg galantamine in rats self administering nicotine on a FR5 schedule of reinforcement (n=10 per treatment). The asterisk represents a significant difference from vehicle, 0.1, and 1.0 mg/kg galantamine (Tukey's HSD, p<0.05). No significant differences in responding on the inactive lever (mean±SEM) were found between treatments. Total active lever responses (b) and total nicotine infused (c) are plotted for animals pretreated with 5.0 mg/kg galantamine prior to nicotine self-administration on a PR schedule of reinforcement (n=11 per treatment). The asterisks represent a significant difference from vehicle (Paired t-test, p<0.001). (d) Total number of lever responses (mean±SEM) in subjects (n=8 per treatment) self-administering food pellets on a FR5 schedule of reinforcement. No significant differences in responding were noted between subjects pretreated with vehicle, 0.5, or 5.0 mg/kg galantamine. FR, fixed ratio; PR, progressive ratio; Self-admin, self-administration.