Figure 5.

Performance of control and MK-801 groups on (a) Cross-modal and unimodal object recognition tasks with an immediate retention delay and (b) additional immediate delay cross-modal trials with acute pre-sample injections of systemic saline or nicotine (0.2 mg/kg). (c) Data from a separate batch of rats prepared specifically to assess the dose–response relationship for the acute nicotine effect in cross-modal object recognition performance. Physiological saline and three doses of nicotine (0.05, 0.2, and 0.8 mg/kg) were administered to rats in counterbalanced order. The selective cross-modal deficits in rats treated sub-chronically with MK-801 were reversed in a dose-dependent manner by acute nicotine. ^*p<0.05; ^**p<0.01.