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. Author manuscript; available in PMC: 2013 Aug 14.
Published in final edited form as: Cancer Cell. 2012 Aug 14;22(2):209–221. doi: 10.1016/j.ccr.2012.06.007

Figure 5. TAL1 positively regulates target genes with GATA3 and RUNX1 in Jurkat cells.

Figure 5

(A, B) GSEA to determine the correlation of DNA binding with gene expression changes upon knockdown (KD) of GATA3 or RUNX1, respectively. See Figure 4A legend for details. (C) Heatmap images representing the relative expression levels of high-confidence TAL1 targets in Jurkat cells with or without knockdown of TAL1 (left), GATA3 (middle) or RUNX1 (right). See Figure 4B legend for details. (D, E) GSEA of expression changes of high-confidence TAL1 targets upon knockdown of GATA3 or RUNX1, respectively. TAL1 target genes (n=238) that were significantly downregulated by TAL1 knockdown (Figure 4B, left) were used as a gene set.