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. 2012 Sep;342(3):799–807. doi: 10.1124/jpet.111.188987

Fig. 3.

Fig. 3.

Effect of total receptor knockout on antinociceptive effect of SNC80 and ADL compounds. Conventional δ-receptor KO mice and their WT counterparts were used for testing. Chronic pain was induced by CFA (A) or SNL (B). The nociceptive threshold was determined before induction of pain (BL), 45 min after SNC80 (10 mg/kg) or vehicle injection, and 60 min after the ADL compound by Von Frey filaments. Both SNC80 and ADL compounds induced analgesic effect in WT mice, whereas these antinociceptions were abolished in KO mice, except for ADL compounds at dose of 100 mg/kg. Data are expressed as means ± S.E.M. of 8 to 10 mice/group. Significance is indicated: ***, P < 0.001, drug-treated group versus vehicle-treated group (two-way ANOVA followed by Bonferroni post hoc test).