Fig. 6.

Locomotor activity after administration of SNC80 and ADL compounds in naive mice. Locomotion (total distance of the movement) was measured automatically by the automatic tracking system immediately after drug administration. A to C, although SNC80 (A) induced significant hyperlocomotion, ADL 5747 (B) and ADL5859 (C) had no effect on locomotor activity. D, total activity shows the hyperlocomotor effect of SNC80 and the absence of effect of the ADL compounds. Data are expressed as means ± S.E.M. of 8 to 10 mice/group. Significance is indicated: *, P < 0.05; **, P < 0.01; ***, P < 0.001, drug-treated group versus vehicle-treated group for individual time points, two-way repeated-measures ANOVA followed by Bonferroni post hoc test (A–C) or Student's t test (D).