Fig. 3.

Dog pharmacokinetics after the single-dose oral administration of l-AMT and l/d-AMT. Ten beagle dogs received l-AMT (0.77 mg of l-enantiomer) and l/d-AMT (0.7 mg of l-enantiomer and 0.3 mg of d-enantiomer) by gavage in a randomized, single-dose, two-way crossover design. Plasma samples were collected over a 12-h period and analyzed by LC-MS/MS as described under Materials and Methods. Pharmacokinetic parameters were derived from the concentration versus time profiles. There was no detectable d-enantiomer in the plasma after dosing of either drug product; values shown are only for the l-enantiomer in plasma. Shown are the mean plasma concentration-time profiles for l-AMT and l/d-AMT, where each concentration value is the mean ± S.D. There was no significant difference between l-AMT and l/d-AMT for any mean pharmacokinetic parameter (p > 0.05).