TABLE 1.
Enantiomer | Dose | Cmax | AUC(0–4 h) | Tmax | Toxicity |
---|---|---|---|---|---|
mg/kg | nM | nM × h | h | ||
l | 0.02 | 19.2 ± 1.1 | 51.5 ± 9.1 | 0.6 ± 0.3 | None |
l | 0.08 | 80.8 ± 26 | 206 ± 100 | 0.9 ± 0.3 | None |
l | 0.2 | 316 ± 79 | 845 ± 124 | 2.3 ± 1.3 | + |
l | 0.8 | 566 ± 130 | 1640 ± 264 | 1.8 ± 0.5 | ++++ |
l | 2.5 | 1050 ± 198 | 3050 ± 721 | 2.0 ± 0.0 | ++++ |
d | 0.8 | 50.0 ± 34 | 134 ± 75 | 1.4 ± 0.8 | None |
d | 2.5 | 174 ± 70 | 488 ± 214 | 2.5 ± 1.0 | None |
d | 8.2 | 543 ± 222 | 1430 ± 627 | 3.0 ± 1.2 | None |
d | 24.7 | 1560 ± 465 | 4450 ± 1364 | 1.3 ± 0.5 | None |
d | 82.5 | 4350 ± 2145 | 11,600 ± 5253 | 2.0 ± 1.4 | None |