TABLE 2.

Pharmacokinetic parameters of l-AMT and l/D-AMT in dogs given the same l-enantiomer dose

l-AMT and l/d-AMT were orally administered to 10 beagle dogs as described under Materials and Methods. Plasma samples were collected over a 12-h period and analyzed by LC-MS/MS. Pharmacokinetic parameters were derived from concentration vs. time profiles. There was no detectable d-enantiomer in the plasma after dosing of either drug product; values shown are only for the l-enantiomer in plasma. Values are mean ± S.D., n = 10 except for GFR/kg, which is the weighted mean (95% CI) as described under Materials and Methods. There was no significant difference between l-AMT and l/d-AMT for any mean pharmacokinetic parameter (p > 0.05).

	l-AMT	l/d-AMT
l dose, mg/kg	0.07 ± 0.01	0.06 ± 0.01
d dose, mg/kg		0.03 ± 0.004
Cmax, nM	90 ± 50	100 ± 50
AUC(0–12 h), nM × h	250 ± 130	330 ± 180
AUC∞, nM × h	270 ± 130	340 ± 180
Tmax, h	1.1 ± 0.5	1.0 ± 0.5
t1/2, h	3.0 ± 1.5	2.1 ± 0.4
CL/kg, l/h/kg	0.80 ± 0.57	0.54 ± 0.31
GFR/kg, l/h/kg	0.24 (0.21–0.26)	0.24 (0.21–0.26)
VD/kg, l/kg	4.2 ± 5.7	1.7 ± 1.0