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. 2012 Sep;342(3):688–695. doi: 10.1124/jpet.112.194803

Fig. 4.

Fig. 4.

Effects of GH and sex hormones on the gender differences in Pon1 mRNA expression in mouse liver from naive, GNX, HX, and lit/lit mice. Total liver RNA was isolated and analyzed by bDNA assay for Pon1 mRNA expression. The data are presented as mean RLU ± S.E.M. (n = 6–7). The study was separated into groups: GNX/HX/Lit + Plac (placebo administered to gonadectomized, hypophysectomized, or lit/lit mice); HX/Lit + MPGH (rat GH twice daily administered by intraperitoneal injection to hypophysectomized or lit/lit mice mimicking male-pattern GH secretion); HX/Lit + FPGH (continuous infusion of GH to hypophysectomized or lit/lit mice via subcutaneously implanted 21-day-release, 1-mg rat GH pellet mimicking female-pattern GH secretion); GNX/HX + DHT (DHT administered to gonadectomized or hypophysectomized mice); and GNX/HX + E2 (E2 administered to gonadectomized or hypophysectomized mice). *, statistical differences (p < 0.05) between male and female mice. †, statistical differences (p < 0.05) between naive mice and the same gender, placebo-treated gonadectomized, hypophysectomized, or lit/lit mice. ‡, statistical differences (p < 0.05) between placebo-treated gonadectomized, hypophysectomized, or lit/lit mice and the same gender, gonadectomized, hypophysectomized, or lit/lit mice after hormone replacement treatment.