TABLE 1.

Half-life, clearance and AUC of [D₁₀]PheT after oral dosing and smoking

Paired t test was performed to compare the effects of routes of administration. Results were not significant, p > 0.05.

ID	t1/2		CL7		AUC(PheT)
	Oral	Smoking	Oral	Smoking	Oral	Smoking
	h		l/h		nmol · h/l
1	7.2	10.9	7.8	13.2	1.07	1.43
2	17.7	8.1	3.1	7.3	0.13	0.11
3	12.6	11.4	5.8	6.4	0.97	1.06
4	11.0	6.7	4.9	6.4	0.37	0.38
5	3.9	4.8	5.5	4.8	0.24	0.48
6	6.3	7.5	4.3	7.3	1.10	1.49
7	12.6	8.1	4.5	13.0	0.97	0.13
8	5.5	5.9	5.4	4.6	0.46	0.51
9	6.4	9.8	3.2	1.3	1.04	0.81
10	6.9	7.5	5.1	7.1	0.55	0.48
11	4.9	4.5	7.5	3.1	0.85	0.70
12	4.4	6.4	3.2	3.6	0.43	0.48
13	7.9	9.9	6.0	7.0	0.58	0.76
14	7.4	7.1	4.0	4.5	1.70	1.11
15	8.8	6.0	4.6	4.0	0.94	0.53
16	5.1	5.2	4.4	4.5	0.93	0.87
17	9.3	7.5	1.9	1.9	1.98	1.27
18	6.1	11.0	2.2	2.2	0.80	0.65
19	5.4	N.A.	1.8	N.A.	0.90	N.A.
20	5.2	6.2	3.7	4.1	1.04	1.02
21	7.4	9.8	3.2	2.9	1.45	0.69
22	5.8	8.9	2.8	4.7	0.82	1.53
23	7.0	6.7	3.0	5.1	2.08	1.45
24	4.8	7.3	5.3	3.0	1.29	1.57
25	6.3	6.9	2.4	2.9	0.65	0.79
Mean	7.4	7.7	4.2	5.2	0.93	0.85
S.D.	3.2	2.0	1.6	3.0	0.49	0.44

N.A., not available because the plasma concentration of [D₁₀]PheT of subject 19 after smoking was below the limit of quantitation.