TABLE 2.

A_act of oral and smoking arm calculated by two methods

Two-way analysis of variance was performed to evaluate the influence of route of administration and data source (plasma, urine), which was found to be not significant, p > 0.05.

ID	Oral Arm				Smoking Arm
	Aact,plasma		Aact,urine		Aact,plasma		Aact,urine
	nmol	% of dose	nmol	% of dose	nmol	% of dose	nmol	% of dose
1	8.25	15.51	5.62	10.56	18.81	35.36	8.00	15.04
2	0.41	0.77	0.28	0.53	0.79	1.48	0.43	0.81
3	5.57	10.47	3.37	6.33	6.74	12.67	3.45	6.48
4	1.79	3.36	1.33	2.50	2.41	4.53	2.06	3.87
5	1.32	2.48	1.49	2.80	2.30	4.32	2.27	4.27
6	4.62	8.68	6.37	11.97	10.77	20.24	7.03	13.21
7	4.36	8.20	3.29	6.18	1.71	3.21	1.08	2.03
8	2.45	4.61	1.89	3.55	2.30	4.32	2.46	4.62
9	3.24	6.09	5.29	9.94	1.00	1.88	3.76	7.07
10	2.83	5.32	2.28	4.29	3.44	6.47	2.22	4.17
11	6.31	11.86	6.11	11.48	2.14	4.02	3.22	6.05
12	1.36	2.56	1.72	3.23	1.73	3.25	1.58	2.97
13	3.43	6.45	2.45	4.61	5.26	9.89	2.96	5.56
14	6.75	12.69	5.85	11.00	4.91	9.23	4.40	8.27
15	4.3	8.08	4.45	8.36	2.10	3.95	3.29	6.18
16	4.08	7.67	4.20	7.89	3.92	7.37	4.13	7.76
17	3.72	6.99	3.89	7.31	2.34	4.40	2.33	4.38
18	1.74	3.27	1.68	3.16	1.39	2.61	0.77	1.45
19	1.59	2.99	1.31	2.46	N.A.	N.A.	0.26	0.49
20	3.83	7.20	3.43	6.45	4.11	7.73	2.86	5.38
21	4.6	8.65	2.66	5.00	1.96	3.68	1.42	2.67
22	2.29	4.30	2.33	4.38	7.14	13.42	4.29	8.06
23	6.24	11.73	5.95	11.18	7.37	13.85	5.26	9.89
24	6.77	12.73	5.63	10.58	4.68	8.80	5.13	9.64
25	1.57	2.95	1.07	2.01	2.31	4.34	1.87	3.52
Mean	3.74	7.02	3.36	6.31	4.23	7.96	3.06	5.75
S.D.	2.06	3.87	1.86	3.50	3.94	7.41	1.91	3.60

N.A., not available because plasma concentration of [D₁₀]PheT after smoking was below the limit of quantitation.