TABLE 4.
Significant lung contribution to metabolic activation in subjects 1, 6, and 22
Data of a typical subject were based on the group mean (n = 25).
| ID |
Aact,plasma |
Aact(lung)a |
Aact,urine |
Aact(lung)b | ||
|---|---|---|---|---|---|---|
| Smoking | Oral | Smoking | Oral | |||
| nmol | ||||||
| 1 | 18.81 | 8.25 | 10.56 | 8.00 | 5.62 | 2.38 |
| 6 | 10.77 | 4.62 | 6.15 | 7.03 | 6.37 | 0.66 |
| 22 | 7.14 | 2.29 | 4.85 | 4.29 | 2.33 | 1.96 |
| A typical subject | 4.23 | 3.74 | 3.06 | 3.36 | ||
a
The difference of Aact,plasma between smoking and oral dosing.
b
The difference of Aact,urine between smoking and oral dosing