Fig. 7.

Ternary complex of Bet v 1a with ANS and DXC. (a) Bet v 1a with ANS and DXC bound in the hydrophobic cavity. (b) Close-up view of ANS and kinetin simultaneously bound to Bet v 1a with the corresponding electron density. Both ligands occupy the same binding sites as identified in the corresponding binary complexes. (c) Comparison of ANS coordination in the binary (pink) and ternary (yellow) complex. The presence of DXC caused a change in the relative orientation of ANS, pointing now towards the protein surface with its sulfonate group.