Fig. 1.

Extended two-compartment model (eqs. 5–8) describing the uptake and metabolism of repaglinide in human hepatocytes over time. S_{Gluc, cell}, S_{M2, cell}, and S_{M4, cell} represent concentrations of major repaglinide metabolites in the cell. CL_{met,gluc, u} is the glucuronidation clearance; K_{m, M2, u}, V_{max, M2}, K_{m, M4, u}, and V_{max, M4} are the Michaelis-Menten parameters describing the concentration-dependent saturation of the formation of M2 and M4. In the case of telmisartan, the model was limited to the parent compound and the glucuronide metabolite.