Fig. 2.

Proportion of total uptake due to active transport and passive diffusion in human hepatocytes over a range of concentrations. Active transport and passive diffusion contributions were estimated using either a generic or extended two-compartment mechanistic model and on the basis of uptake kinetic estimates obtained in human hepatocyte donors HU4122 (black line), HU4199 (red line), and HU8089 (green line). ——, proportion of active transport; – – –, proportion of passive diffusion. A, rosuvastatin; B, repaglinide; C, bosentan; D, pitavastatin; E, pravastatin; F, telmisartan; G, valsartan.