. 2012 Sep;40(9):1744–1756. doi: 10.1124/dmd.112.046193

TABLE 3.

Uptake kinetic parameters of rosuvastatin estimated in three human hepatocyte donors using a mechanistic two-compartment model

Uptake kinetics was measured in cryopreserved human hepatocytes plated for 6 h over 2 min at seven concentrations (0.1–300 μM).

Donor	K_{m, u}	V_max	P_{diff, u}	fu_med	CL_{active, u}
	μM	pmol · min⁻¹ · 10⁶ cells⁻¹	μl · min⁻¹ · 10⁶ cells⁻¹		μl · min⁻¹ · 10⁶ cells⁻¹
HU4122	11.2	104	0.391	0.80	9.21
HU4199	9.80	16.6	0.148	1	1.69
HU8089	12.0	16.3	0.243	0.96	1.35
Mean ± S.D.	11.0 ± 1.1	45.5 ± 50.3	0.261 ± 0.123	0.93 ± 0.13	4.09 ± 4.44