TABLE 4.

Empirical scaling factors applied to the active uptake clearances to recover the intrinsic uptake clearance in human livers

Drug	Scaling Factor			Mean
	HU4122	HU4199	HU8089
Bosentan	16.1	13.0	24.8	17.9 ± 6.1
Pravastatin	6.67	ND	ND	6.67
Repaglinide	4.70	39.2	17.7	20.5 ± 17.4
Rosuvastatin	9.75	51.9	65.3	42.3 ± 29.0
Telmisartan	3.23	18.7	17.9	13.3 ± 8.7
Valsartan	0.740	2.00	2.20	1.64 ± 0.79
Mean	6.87 ± 5.46	25.0 ± 20.2	25.6 ± 23.7	17.1 ± 18.8

N.D., not determined, because CL_{uptake, u} could not be measured accurately at a single concentration.