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Serum VPA concentrations in Sprague-Dawley control (a; filled symbols) and charcoal-treated (a; open symbols) rats, Sprague-Dawley control (b; filled symbols) and antibiotic-treated (b; open symbols) rats, and Wistar wild-type (c; filled symbols) and Mrp2-deficient (c; open symbols) rats after a 75 mg/kg bolus dose of VPA. Symbols indicate sample mean, and bars represent S.D. Lines are included to emphasize temporal relationships.
