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. Author manuscript; available in PMC: 2012 Aug 18.
Published in final edited form as: Cell. 2010 Apr 15;141(3):472–482. doi: 10.1016/j.cell.2010.03.041

Figure 5. Myristoyl Group of the Primed VP5 in the ISVP.

Figure 5

(A) Positions of three myristoyl groups (red balls) near the base of the VP5 trimer. See also Movie S4.

(B) Cryo-EM density (gray mesh) of the base region in Figure 5A (red box), superimposed with its atomic model (magenta), showing the myristoyl group (red balls and sticks) inside a hydrophobic pocket. See also Movie S4.

(C) Amide linkage of the myristoyl group to Gly2.

(D) Changes of the penetration protein VP5 from a stable, dormant state to a metastable, primed ISVP state and subsequently to the ISVP* state. Red, base domain (2-242); green, linker domain (243-286 & 485-648) and cyan, jelly-roll domain (287-484). The myristoyl group (myr) in the hydrophobic pocket is enclosed by an ellipse; the released myristoyl group has no ellipse.