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. Author manuscript; available in PMC: 2013 Mar 1.
Published in final edited form as: Neuroscience. 2011 Aug 16;204:117–124. doi: 10.1016/j.neuroscience.2011.08.021

Figure 1.

Figure 1

The effect of the cannabinoid antagonist AM-251 on forced swim- and cocaine-induced reinstatement. Data represent the time spent in the cocaine-paired compartment (mean +/- SEM) during the extinction session prior to reinstatement testing and after reinstatement testing with forced swim (6 minutes) + vehicle (FS), FS + AM-251(3 mg/kg, i.p.) (FS+AM), cocaine (15 mg/kg, i.p) + vehicle (Coc), cocaine + AM-251 (Coc+AM), vehicle, or AM-251. Vehicle and AM-251 were injected 30 minutes prior to reinstatement testing. Coc and FS were administered immediately prior to reinstatement testing. A significant increase in the time spent in the cocaine-paired compartment during reinstatement testing compared to the preceding extinction session was seen after both FS and cocaine (* =p<0.05, Holm-Sidak multiple comparison test) but not after AM-251 or vehicle alone. A significant difference between the time spent in the cocaine-paired compartment on reinstatement days was seen between the FS and FS+AM251 treatment groups (@ = p<0.05, Holm-Sidak multiple comparison test) but not between the Coc and the Coc + AM-251 groups.