Table 2.

Pharmacokinetic parameters in mice after i.v. administration of single drug-loaded, 2-in-1, or 3-in-1 PEG-b-PLA micelles containing PTX, 17-AAG, and/or RAP (mean ± SD, n = 4–5).

	Drug(s)	Dose (mg/kg)	AUC (μg*h/mL)	CL (L/h/kg)	MRT (h)	Vd,ss (L/kg)	t1/2 (h)
Single-drug loaded	PTX	60	148 17 ± 27.54	0.42 ± 0.07	1.76 ± 0.57	0.85 ± 0.15	1.46 ± 0.04
	17-AAG	60	28.31 ± 1.44	2.12 ± 0.11	0.58 ± 0.09	1.71 ± 0.30	0.56 ± 0.10
	RAP	30	100.88 ± 39.76	0.33 ± 0.12	10.13 ± 4.84	3.12 ± 0.25	7.36 ± 3.14
2-in-1	PTX +	60	171.86 ± 12.11	0.35 ± 0.02	2.07 ± 0.24	0.76 ± 0.19	1.49 ± 0.28
	17-AAG	60	36.50 ± 3.59	1.66 ± 0.16	0.63 ± 0.03	1.20 ± 0.19	0.50 ± 0.04
	PTX +	60	162.81 ± 17.55	0.37 ± 0.03	1.42 ± 0.20	0.43 ± 0.04	0.81 ± 0.10
	RAP	30	95.93 ± 15.14	0.32 ± 0.05	7.72 ± 2.20	2.67 ± 0.42	6.02 ± 1.82
	17-AAG +	60	29.88 ± 1.06	2.01 ± 0.07	0.60 ± 0.09	1.49 ± 0.14	0.52 ± 0.05
	RAP	30	144.90 ± 6.44	0.21 ± 0.01	8.89 ± 0.28	1.93 ± 0.08	6.45 ± 0.30
3-in-1	PTX +	60	245.06 ± 15.16	0.25 ± 0.02	2.14 ± 0.37	0.46 ± 0.07	1.31 ± 0.25
	17-AAG +	60	29.72 ± 5.78	2.10 ± 0.49	0.58 ± 0.07	1.86 ± 0.82	0.60 ± 0.11
	RAP	30	161.58 ± 23.73	0.19 ± 0.03	10.55 ± 2.46	2.04 ± 0.25	7.68 ± 1.90