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. Author manuscript; available in PMC: 2013 Oct 10.
Published in final edited form as: J Control Release. 2012 Apr 23;163(1):93–99. doi: 10.1016/j.jconrel.2012.04.024

Table 2.

Pharmacokinetic parameters in mice after i.v. administration of single drug-loaded, 2-in-1, or 3-in-1 PEG-b-PLA micelles containing PTX, 17-AAG, and/or RAP (mean ± SD, n = 4–5).

Drug(s) Dose (mg/kg) AUC (μg*h/mL) CL (L/h/kg) MRT (h) Vd,ss (L/kg) t1/2 (h)
Single-drug loaded PTX 60 148 17 ± 27.54 0.42 ± 0.07 1.76 ± 0.57 0.85 ± 0.15 1.46 ± 0.04
17-AAG 60 28.31 ± 1.44 2.12 ± 0.11 0.58 ± 0.09 1.71 ± 0.30 0.56 ± 0.10
RAP 30 100.88 ± 39.76 0.33 ± 0.12 10.13 ± 4.84 3.12 ± 0.25 7.36 ± 3.14

2-in-1 PTX + 60 171.86 ± 12.11 0.35 ± 0.02 2.07 ± 0.24 0.76 ± 0.19 1.49 ± 0.28
17-AAG 60 36.50 ± 3.59 1.66 ± 0.16 0.63 ± 0.03 1.20 ± 0.19 0.50 ± 0.04
PTX + 60 162.81 ± 17.55 0.37 ± 0.03 1.42 ± 0.20 0.43 ± 0.04 0.81 ± 0.10
RAP 30 95.93 ± 15.14 0.32 ± 0.05 7.72 ± 2.20 2.67 ± 0.42 6.02 ± 1.82
17-AAG + 60 29.88 ± 1.06 2.01 ± 0.07 0.60 ± 0.09 1.49 ± 0.14 0.52 ± 0.05
RAP 30 144.90 ± 6.44 0.21 ± 0.01 8.89 ± 0.28 1.93 ± 0.08 6.45 ± 0.30

3-in-1 PTX + 60 245.06 ± 15.16 0.25 ± 0.02 2.14 ± 0.37 0.46 ± 0.07 1.31 ± 0.25
17-AAG + 60 29.72 ± 5.78 2.10 ± 0.49 0.58 ± 0.07 1.86 ± 0.82 0.60 ± 0.11
RAP 30 161.58 ± 23.73 0.19 ± 0.03 10.55 ± 2.46 2.04 ± 0.25 7.68 ± 1.90