Fig. 1.

No weight loss and fewer oligodendroglial apoptoses in LAQ-treated mice. a At all time points, mice treated with 25 mg/kg LAQ (n = 9) display higher body weights than controls (n = 10) during 0.25 % cuprizone challenge (p < 0.001). Data are expressed as mean values with standard error of the mean (SEM). b Apoptotic cells staining positively for active caspase-3 and displaying apoptotic bodies are detected in both groups (scale bar 5 μm, shown for an untreated control), but c shows that LAQ-treated mice (n = 10) display significantly fewer caspase-3-positive apoptoses in the corpus callosum than controls (n = 10) after 1 week of 0.25 % cuprizone (*** p < 0.001)