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. Author manuscript; available in PMC: 2012 Oct 1.
Published in final edited form as: Curr Opin Anaesthesiol. 2011 Oct;24(5):532–539. doi: 10.1097/ACO.0b013e32834a1091

Figure 2. Glutamate levels in the posterior insula are negatively correlated with experimental pressure pain testing.

Figure 2

Medium pressure thresholds from fibromyalgia patients (solid circles) and control patients (open circles) are displayed in this scatterplot, along with a regression line across both groups. Fibromylagia patients demonstrated higher central glutamate levels and corresponding lower pain thresholds; however, the correlation between higher glutamate levels and lower pain thresholds was also demonstrated in the control group. Glx = glutamate (From Harris, R.E., et al., Elevated insular glutamate in fibromyalgia is associated with experimental pain. Arthritis Rheum, 2009. 60(10): p. 3146-52 with permission)