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. 2012 Jul 11;32(28):9485–9498. doi: 10.1523/JNEUROSCI.0311-12.2012

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Copyright © 2012 the authors 0270-6474/12/329485-14$15.00/0

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Figure 8. — Assessment of hearing in Clrn1^N48/K/N48K knock-in compared with the Clrn1^−/− mice over time. The plot shows that mean ABR thresholds of Clrn1^N48K/N48K mice (n = 25) are significantly elevated compared with the thresholds of Clrn1^+/N48K mice (n = 6), which displayed wild-type thresholds at all time points tested. The plot also shows that ABR thresholds of Clrn1^N48K/N48K mice are significantly lower compared with Clrn1^−/− mice (n = 12) at P18 and P21; the difference is not significant at P24 because mice from both groups display profound hearing loss at P24. *p < 0.0001.