Characterization of 2008 Sec61β-KD cells. A, relative Sec61β mRNA levels in parental 2008 wild-type (WT) cells and 2008 Sec61β-KD cells, as measured in qRT-PCR assays. B, Western blot analysis of Sec61β protein levels. Vertical bars, S.D. C–E, concentration-survival curves for parental 2008 wild-type and 2008 Sec61β-KD cells with cDDP (C), carboplatin (D), and oxaliplatin (E), as measured with the sulforhodamine B assay. Survival data were plotted on a logarithmic scale. Vertical bars, S.E.M.