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Effect of Sec61β knockdown on platinum accumulation. A, whole-cell platinum accumulation in 2008 wild-type (WT) and 2008 Sec61β-KD cells after 1-h exposure to 30 μM cDDP, as measured with ICP-MS. B, extent of DNA-platinum adduct formation after the same treatment as in A. Vertical bars, S.E.M.
