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6-AziP modulation of [35S]TBPS binding to β3 homomeric GABAA receptors in Sf9 cell membranes, rat brain membranes, and α1β2 GABAA receptors expressed in TSA cells. 6-AziP produced one-component inhibition of [35S]TBPS binding to the recombinant His8-β3 homomeric GABAA receptors (IC50 = 9.0 ± 1 μM), whereas it produced two-component (enhancement and inhibition) modulation with rat brain membranes and α1β2 receptors.
