Fig. 5.

Vm24 selectivity for Kv1.3 channels. A, remaining current fractions for the indicated channels with equilibrium block by Vm24, applied at 10 nM. Data are presented as mean ± S.E.M. for three or more independent experiments. B, remaining current fractions for channels that were partially blocked with 10 nM toxin and were tested again with 1 nM Vm24. C, effects of 1 nM Vm24 on Kv1.1, Kv1.2, and KCa3.1 currents. Current traces recorded before the application of the toxin (control), after the equilibration of blockade by 1 nM Vm24, and after wash out (wash) of the toxin are indicated (for details on the expression systems, solutions, and voltage protocols, see Materials and Methods).