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T cell and APC interaction stages. (A) In the first stage, T cells scan APC surface for specific peptide loaded on MHC class molecule. (B) Once CD4+ T cell find a specific MHCp, pseudopodia-like structures are established. T cell starts to polarize. (C) Immunological synapse is formed and sustained; centrioles are translocated proximally to IS. (D) Termination of immunological synapse; organelles lose their polarity.
