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. Author manuscript; available in PMC: 2013 Jul 24.
Published in final edited form as: Circulation. 2012 Jun 15;126(4):418–429. doi: 10.1161/CIRCULATIONAHA.112.112185

Figure 1.

Figure 1

IL10 improves left ventricular (LV) functions & attenuates ISO-induced hypertrophic remodeling. WT and KO mice were treated with ISO and IL10 as described. After serial Echocardiographic analysis mice were euthanized and heart tissue was extracted for biochemical analysis. a). M-mode echocardiography indicated that chronic ISO treatments exaggerated chamber size and reduced wall thicknesses in KO compared to WT mice & IL10 significantly reversed this effect. b & c). ISO-induced decreased FS and EF were significantly improved by IL10. d). Chronic ISO treatment markedly increased left ventricular mass, which was significantly recovered by IL10. e & f). Heart weight and tibia length ratio were calculated at 7 and 28 days respectively. ISO treatment significantly increased this ratio; however IL10 markedly abolished ISO effect. *** p<0.001 vs. respective vehicle, ###p<0.001 vs. respective ISO treated, ##p<0.01 vs. respective ISO treated. N=6–8.