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. Author manuscript; available in PMC: 2013 Jul 24.
Published in final edited form as: Circulation. 2012 Jun 15;126(4):418–429. doi: 10.1161/CIRCULATIONAHA.112.112185

Figure 4.

Figure 4

IL10 treatment diminishes TAC-induced left ventricular fibrosis. Masson`s Trichome staining was performed to check the collagen deposition in LV tissue sections. Stained sections were analyzed with Image-Pro Plus 6.3 software. a–c). TAC significant increased interstitial and perivascular fibrosis. TAC-induced increased fibrosis was attenuated by IL10 treatment. OM=20X. d & e). Matrix metalloproteinase activity was measured in whole tissue lysates by gelatin zymography. A significant increase in MMP2 activity was observed in constricted animals. IL10 treatment largely abolished the TAC induced MMP2 activity. ***p<0.001 vs. sham, **p<0.01 vs. sham, ##p<0.01 vs. WT-TAC (N=4–5).