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. Author manuscript; available in PMC: 2013 Jun 1.
Published in final edited form as: Biochim Biophys Acta. 2011 Dec 7;1818(6):1536–1544. doi: 10.1016/j.bbamem.2011.11.034

Figure 5. Modulation of mitochondrial membrane potential by free tubulin and protein kinase.

Figure 5

A. Pseudocolor of the fluorescence of TMRM was used to monitor changes of mitochondrial Ψ in HepG2 human hepatoma cells. Ψ decreased after microtubule depolymerization with colchicine (Col) and nocodazole (Ncz). Paclitaxel (Ptx), microtubule stabilizer, hyperpolarized mitochondria even in the presence of nocodazole. Dibutyrl cAMP (cAMP), a PKA agonist, also depolarized mitochondria, whereas H89, a PKA inhibitor, hyperpolarized mitochondria even in the presence of dibutyrl cAMP. Adapted from [52].