Fig. 10.

Schematic representation of the two SHP-1 transcripts transcribed via promoter I and II. The gray boxes represent the exons that can form the SH-2 binding domains or the catalytic domain. Both transcripts translate into identical isoforms except at the N-terminus where the isoform driven from promoter I, SHP-1 (I), has the amino acids MLSG and the isoform driven by promoter II, SHP-1 (II) has the amino acids MVR. Promoter I is upstream of exon I and contains consensus sequences that can bind NF-κB, IRF-1, and SP-1. Promoter II is found between exon 1 and 2 and has several STAT-3 binding sites. The table lists the nucleotide sequences of the cis-regulatory elements found either in Promoter I or in Promoter II both in human and mouse.