Table 3.
List of Factors Related to Chemotherapy Resistance in Pancreatic Cancer
| Factors | Description | Antagonist | References |
|---|---|---|---|
| CXCL12-CXCR4 (chemokine receptor) | Activation of FAK, ERK, Akt, β-catenin and NF-κB | AMD3100 | [181] |
| Multidrug resistance protein 5 (MRP5) | Gemcitabine and 5-FU upregulate MRP5 | SiRNA | [182–184] |
| MUC1 | Overexpressed MUC1 decrease intracellular drug concentration | Genzyl-α, GalNAC | [185] |
| 14-3-3σ | Increases cell cycle arrest upon DNA damage, resistant to drug induced apoptosis | SiRNA | [186] |
| TMS1 | TMS1, a pro-apoptotic gene was silenced by methylation | Azacitidine, decitabine | [187, 188] |
| Notch signaling | Anti-apoptosis through activation of PI3K/Akt | MK0752, RO4929097 | [177, 189–191] |