Table 4.
Results of multivariate analysis of colon cancer survival stratified according to body mass index category
| Underweight | Normal weight | Overweight | Obese | |
| All patients (n = 2138) | ||||
| Overall survival | ||||
| HR (95% CI)1 | 1.58 (1.23-2.05) | Reference | 0.83 (0.68-1.01) | 0.94 (0.74-1.18) |
| P value2 | < 0.001 | 0.060 | 0.578 | |
| Disease-free survival | ||||
| HR (95% CI)1 | 1.49 (1.16-1.93) | Reference | 0.86 (0.71-1.04) | 1.00 (0.79-1.25) |
| P value2 | 0.002 | 0.123 | 0.972 | |
| Cancer-specific survival | ||||
| HR (95% CI)1 | ||||
| P value2 | 1.33 (0.94-1.87) | Reference | 0.96 (0.76-1.22) | 1.06 (0.80-1.41) |
| 0.107 | 0.751 | 0.677 | ||
| Males (n = 1109) | ||||
| Overall survival | ||||
| HR (95% CI) | 1.55 (1.03-2.35) | Reference | 0.77 (0.58-1.01) | 0.91 (0.66-1.25) |
| P value2 | 0.036 | 0.056 | 0.565 | |
| Disease-free survival | ||||
| HR (95% CI)1 | 1.60 (1.04-2.44) | Reference | 0.84 (0.65-1.09) | 1.01 (0.75-1.37) |
| P value2 | 0.031 | 0.192 | 0.937 | |
| Cancer-specific survival | ||||
| HR (95% CI)1 | ||||
| P value2 | 1.46 (0.84-2.52) | Reference | 0.96 (0.69-1.32) | 1.21 (0.83-1.77) |
| 0.179 | 0.789 | 0.328 | ||
| Females (n = 1029) | ||||
| Overall survival | ||||
| HR (95% CI)1 | 1.55 (1.11-2.16) | Reference | 0.95 (0.71-1.27) | 0.99 (0.69-1.41) |
| P value2 | 0.011 | 0.724 | 0.945 | |
| Disease-free survival | ||||
| HR (95% CI)1 | 1.41 (1.01-1.97) | Reference | 0.91 (0.68-1.22) | 1.01 (0.71-1.43) |
| P value2 | 0.042 | 0.544 | 0.957 | |
| Cancer-specific survival | ||||
| HR (95% CI)1 | ||||
| P value2 | 1.16 (0.75-1.82) | Reference | 0.96 (0.69-1.36) | 0.93 (0.60-1.43) |
| 0.508 | 0.839 | 0.727 | ||
1
HR was calculated using the Cox regression model; the variables in the multivariate analysis included TNM stage, age, gender (when analyzing all patients), comorbidities, CEA, hemoglobin, albumin, operative timing, postoperative morbidity, tumor location, histologic type, and histologic grade;
2
Each category compared to normal-weight patients. HR: Hazard ratio; CI: Confidence interval; BMI: Body mass index; TNM: Tumor, nodes, metastasis; CEA: Carcinoembryonic antigen.