Figure 1.
Prototype reasoning system architecture: a prototype implementation of the PEMRIC model. SuperCYP is our primary source for genotype–phenotype association knowledge. PharmGKB is our primary source for pharmacokinetic pathway knowledge. The clinical data source contains patient data. The dashed line linking PharmGKB to the evidence base represents the inclusion of PharmGKB curated publications into the evidence base only for the drug-oriented approach. The user interface element is included for illustrative purposes.