Figure 2. Myelodysplasia in OCD ^fl/fl mice.

a, Leukopenia with variable anemia (p=0.16) and thrombocytopenia (p=0.08) in OCD ^fl/fl mice (n=10). b, blood smears showing dysplastic hyperlobulated nuclei in granulocytes c, bone marrow sections showing micro-megakaryocytes with hyperchromatic nuclei d, increased apoptosis of hematopoietic progenitor cells in OCD ^fl/fl mice. (n=4) e, increased proliferation of hematopoietic progenitor cells as shown by in vivo BRDU labeling (n=4). Data are mean ± s.e.m. * p≤0.05, **p≤0.01. RBC=red blood cells, LKS= lineage ⁻C-kit⁺ Sca1⁺ cells LKS-SLAM= lineage ⁻C-kit⁺ Sca1⁺ CD150⁺ CD48⁻ cells L-K+= lineage⁻c-kit⁺ cells L-K-int=lineage⁻ Ckit ^intermediate, BRDU= bromodeoxyuridine. For further details see supplementary information.