FIG. 5.
Continuous administration of ramipril results in a significant increase in plasma Ang I and Ang-(1–7), but not Ang II. Panel A: Ang I levels; panel B: Ang II levels; panel C: Ang-(1–7) levels. Rats received either sham irradiation (Sham), 40 Gy of fractionated whole-brain irradiation (fWBI), sham irradiation +15 mg/L of ramipril in the drinking water (Sham + Ram), or 40 Gy of fractionated whole-brain irradiation + ramipril (fWBI + Ram). Ramipril was continuously administered to the rats starting 3 days before the beginning of fractionated whole-brain irradiation. Data represent mean ± SEM; n = 6 rats/group; * P < 0.05.