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. Author manuscript; available in PMC: 2012 Aug 20.
Published in final edited form as: Front Biosci. 2012 Jun 1;17:2237–2246. doi: 10.2741/4047

Figure 2.

Figure 2

Possible mechanisms for arginine to enhance mitochondrial biogenesis and growth of brown adipose tissue in animals. NO, nitric oxide; eNOS, endothelial NO synthase; cGMP, cyclic guanosine monophosphate; SIRT1, Silent mating type information regulator 2 homolog 1; NRF-1/2, nuclear respiratory factor 1/2; Tfam, mitochondrial transcription factor A; PGC, peroxisome proliferator-activated receptor-gamma coactivator; mTOR, mammalian target of rapamycin; 4E-BP1, eukaryotic initiation factor 4E-binding protein-1; S6, ribosomal protein S6 kinase.